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Orcinol

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases[1][2][3].

Product Specifications

CAS Number

[504-15-4]

Product Name Alternative

3,5-Dihydroxytoluene

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

ERK; Fluorescent Dye; p38 MAPK; Tyrosinase

Type

Dye Reagents

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/orcinol.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(C)=CC(O)=C1

Molecular Formula

C7H8O2

Molecular Weight

124.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Murakami Y, et al. The Radical Scavenging Activity and Cytotoxicity of Resveratrol, Orcinol and 4-Allylphenol and their Inhibitory Effects on Cox-2 Gene Expression and Nf-κb Activation in RAW264.7 Cells Stimulated with Porphyromonas gingivalis-fimbriae. In Vivo. 2015 May-Jun;29 (3) :341-9.|[2]Yu C L, et al. Orcinol inhibits melanogenesis in B16F10 cells via the upregulation of the MAPK/ERK signaling pathway[J]. Natural Product Communications, 2023, 18 (3) : 1934578X231156704.|[3]Edwards MJ, et al. Acid loads induced by the detoxification of plant secondary metabolites do not limit feeding by common brushtail possums (Trichosurus vulpecula) . J Comp Physiol B. 2010 Feb;180 (2) :247-57.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-D0168/Orcinol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-D0168/Orcinol-SDS-MedChemExpress.pdf

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Isoform

COX-2

Available Sizes

Curated Selection

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