HBX 19818

HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM.

Product Specifications

CAS Number

[1426944-49-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HBX-19818.html

Purity

99.25

Solubility

1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 20 mg/mL (ultrasonic)

Smiles

CN(CCCNC(C1=CC=C(N=C(CCCC2)C2=C3Cl)C3=C1)=O)CC4=CC=CC=C4

Molecular Formula

C25H28ClN3O

Molecular Weight

421.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Reverdy C, et al. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem Biol. 2012 Apr 20;19 (4) :467-77.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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