PDD 00017273
PDD 00017273 is a potent inhibitor of Poly (ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2].
Product Specifications
CAS Number
1945950-21-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PDD_00017273.html
Purity
99.64
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC2=C(N(CC3=CC(C)=NN3C)C(N(CC4=CN=C(C)S4)C2=O)=O)C=C1)(NC5(C)CC5)=O
Molecular Formula
C23H26N6O4S2
Molecular Weight
514.62
Precautions
H302, H315, H319
References & Citations
[1]James DI, et al. First-in-Class Chemical Probes against Poly (ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to AZD2281. ACS Chem Biol. 2016 Nov 18;11 (11) :3179-3190. Epub 2016 Oct 12.|[2]Gravells P, et al. Specific killing of DNA damage-response deficient cells with inhibitors of poly (ADP-ribose) glycohydrolase. DNA Repair (Amst) . 2017 Apr;52:81-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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