PDD 00017273

PDD 00017273 is a potent inhibitor of Poly (ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2].

Product Specifications

CAS Number

[1945950-21-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Poly (ADP-ribose) Glycohydrolase (PARG)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PDD_00017273.html

Purity

99.64

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(C1=CC2=C(N(CC3=CC(C)=NN3C)C(N(CC4=CN=C(C)S4)C2=O)=O)C=C1)(NC5(C)CC5)=O

Molecular Formula

C23H26N6O4S2

Molecular Weight

514.62

Precautions

H302, H315, H319

References & Citations

[1]James DI, et al. First-in-Class Chemical Probes against Poly (ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to AZD2281. ACS Chem Biol. 2016 Nov 18;11 (11) :3179-3190. Epub 2016 Oct 12.|[2]Gravells P, et al. Specific killing of DNA damage-response deficient cells with inhibitors of poly (ADP-ribose) glycohydrolase. DNA Repair (Amst) . 2017 Apr;52:81-91.