Adamantanine

Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5[1].

Product Specifications

CAS Number

[42381-05-5]

Product Name Alternative

2-Aminoadamantane-2-carboxylic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Aminopeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adamantanine.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

OC(C1([C@H]2C[C@H](C3)C[C@@H]1C[C@H]3C2)N)=O

Molecular Formula

C11H17NO2

Molecular Weight

195.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Nagasawa HT, et al., Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem. 1975 Aug;18 (8) :826-30.|[2]Nagaswa HT, et al., 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16 (7) :823-6.