CM-579 trihydrochloride
CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
Product Specifications
CAS Number
2448471-08-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA Methyltransferase; Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CM-579_hydrochloride.html
Purity
97.00
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 37.5 mg/mL (ultrasonic)
Smiles
CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl
Molecular Formula
C29H43Cl3N4O3
Molecular Weight
602.04
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNA Methyltransferase; DNMT1; DNMT3
Available Sizes
Frequently Asked Questions
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