CM-579 trihydrochloride

CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

Product Specifications

CAS Number

[2448471-08-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA Methyltransferase; Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CM-579_hydrochloride.html

Purity

97.00

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 37.5 mg/mL (ultrasonic)

Smiles

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl

Molecular Formula

C29H43Cl3N4O3

Molecular Weight

602.04

Precautions

H302, H315, H319, H335

References & Citations

[1]San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.