KB-5492 (free base)

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di (2-tolyl) guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].

Product Specifications

CAS Number

[113594-64-2]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kb-5492-free-base.html

Purity

99.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1=CC=C(OC)C=C1)CN2CCN(CC3=CC(OC)=C(OC)C(OC)=C3)CC2

Molecular Formula

C23H30N2O6

Molecular Weight

430.49

References & Citations

[1]Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256 (3) : 321-8.|[2]Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64 (1) : 41-7.