Dihydromethysticin

Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma[1][2][3][4][5].

Product Specifications

CAS Number

[19902-91-1]

Product Name Alternative

(+) -Dihydromethysticin

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Carboxylesterase (CES) ; NOD-like Receptor (NLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dihydromethysticin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(OC)C[C@H](CCC2=CC=C(OCO3)C3=C2)O1

Molecular Formula

C15H16O5

Molecular Weight

276.29

Precautions

H302

References & Citations

[1]Pan H, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020 Jun;59 (6) :575-589.|[2]Melchert PW, et al. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. Chem Biol Interact. 2022 Apr 25;357:109883.|[3]Narayanapillai SC, et al. Dietary Dihydromethysticin Increases Glucuronidation of 4- (Methylnitrosamino) -1- (3-Pyridyl) -1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Drug Metab Dispos. 2016 Mar;44 (3) :422-7.|[4]Hu Q, et al. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. Chem Res Toxicol. 2020 Jul 20;33 (7) :1980-1988.