LRRK2-IN-14

LRRK2-IN-14 (Compound 8) is an orally active LRRK2 inhibitor. LRRK2-IN-14 has an IC50 of 6.3 nM for LRRK2 (G2019S) cell activity.LRRK2-IN-14 has an inhibitory effect on hERG (IC50=22 μM) . LRRK2-IN-14 has blood-brain barrier permeability[1].

Product Specifications

CAS Number

[2942328-06-3]

UNSPSC

12352005

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lrrk2-in-14.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C=C(C(N(CCCNC3=NC(N2)=NC=C3C(F)(F)F)C)=O)C=C1

Molecular Formula

C17H18F3N5O2

Molecular Weight

381.35

References & Citations

[1]Kim K, et al. Concurrent Optimizations of Efficacy and Blood-Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson's Disease Therapeutics. J Med Chem. 2024 May 9;67 (9) :7647-7662.