Obtusifolin
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].
Product Specifications
CAS Number
477-85-0
UNSPSC
12352005
Hazard Statement
H302
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/obtusifolin.html
Purity
99.91
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H302
References & Citations
[1]Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33 (4) :919-928.|[2]Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62 (49) :11933-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB
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