BMS-262084
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM) . BMS-262084 exhibits antithrombotic effects[1][2].
Product Specifications
CAS Number
253174-92-4
UNSPSC
12352005
Target
Factor Xa; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-262084.html
Purity
98.41
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)(NC(N1CCN(C(N2[C@H](C(O)=O)[C@@H](CCCNC(N)=N)C2=O)=O)CC1)=O)C
Molecular Formula
C18H31N7O5
Molecular Weight
425.48
References & Citations
[1]Schumacher WA, et, al. Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats. Eur J Pharmacol. 2007 Sep 10;570 (1-3) :167-74.|[2]Qian X, et, al. A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor. J Org Chem. 2002 May 31;67 (11) :3595-600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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