(E) -Cardamonin

(E) -Cardamonin ((E) -Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

Product Specifications

CAS Number

[19309-14-9]

Product Name Alternative

(E) -Cardamomin; (E) -Alpinetin chalcone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; TRP Channel

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Cardamonin.html

Purity

99.84

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2

Molecular Formula

C16H14O4

Molecular Weight

270.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang S, et al. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21 (9) . pii: E1145.|[2]Park MK, et al. Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 andtransglutaminase-2. Pharmacol Biochem Behav. 2014 Mar;118:10-5.