5- (Nonyloxy) tryptamine (oxalate)

5- (Nonyloxy) tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED50 value of 68 nM. 5- (Nonyloxy) tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells[1][2].

Product Specifications

CAS Number

[157798-13-5]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-nonyloxy-tryptamine-oxalate.html

Smiles

NCCC1=CNC2=C1C=C(OCCCCCCCCC)C=C2.O=C(O)C(O)=O

Molecular Formula

C21H32N2O5

Molecular Weight

392.49

References & Citations

[1]Glennon R A, et al. 5- (Nonyloxy) tryptamine: a novel high-affinity 5-HT1D. Beta. Serotonin receptor agonist[J]. Journal of medicinal chemistry, 1994, 37 (18) : 2828-2830.|[2]Stachura P, et al. Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors. Mol Cancer. 2023 Aug 15;22 (1) :136. doi: 10.1186/s12943-023-01833-8. PMID: 37582744; PMCID: PMC10426104.