Diethyl butylmalonate

Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log (IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease[1][2].

Product Specifications

CAS Number

[133-08-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/diethyl-butylmalonate.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(OCC)C(CCCC)C(OCC)=O

Molecular Formula

C11H20O4

Molecular Weight

216.27

Precautions

H302, H315, H319, H335

References & Citations

[1]T I Netzeva, et al. Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis. SAR QSAR Environ Res. 2003 Aug;14 (4) :265-83.|[2]Yuan L, et al. Diethyl butylmalonate attenuates cognitive deficits and depression in 5xFAD mice. Front Neurosci. 2024 Nov 11;18:1480000.