L-Homocysteic acid

L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM) . L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3].

Product Specifications

CAS Number

[14857-77-3]

Product Name Alternative

L-HCA

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-homocysteic-acid.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 100 mg/mL

Smiles

O=C(O)[C@@H](N)CCS(=O)(O)=O

Molecular Formula

C4H9NO5S

Molecular Weight

183.18

Precautions

H302, H315, H319, H335

References & Citations

[1]M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82 (5) :2820-6. |[2]J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19 (5) :597-602. |[3]B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855 (2) :292-7. |[4]P Mares, et al. Convulsant action of D, L-homocysteic acid and its stereoisomers in immature rats. |[5]Katherine L Nicholson, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl) . 2009 Apr;203 (2) :441-51.