Prim-O-glucosylcimifugin
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling.
Product Specifications
CAS Number
[80681-45-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; NO Synthase; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Prim-O-glucosylcimifugin.html
Purity
99.87
Solubility
DMSO : ≥ 150 mg/mL
Smiles
COC1=C(C[C@@H](C(C)(O)C)O2)C2=CC(OC(CO[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=C4)=C1C4=O
Molecular Formula
C22H28O11
Molecular Weight
468.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou J, et al. Prim-O-glucosylcimifugin Attenuates Lipopolysaccharideinduced Inflammatory Response in RAW 264.7 Macrophages. Pharmacogn Mag. 2017 Jul-Sep;13 (51) :378-384.|[2]Chen N, et al. Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2013 Jun;16 (2) :139-47.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; iNOS
Available Sizes
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