CRTh2 antagonist 4

CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM) . CRTh2 antagonist 4 can be used in the study of severe allergic diseases[1].

Product Specifications

CAS Number

[916046-55-4]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/crth2-antagonist-4.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CN1C(C2(C(N(CC3=CC=CC=C3F)C(C2)=O)=O)C4=C1C=CC(Cl)=C4)=O

Molecular Formula

C20H14ClFN2O5

Molecular Weight

416.79

References & Citations

[1]Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem. 2008 Apr 10;51 (7) :2227-43.