Asfotase alfa
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 / knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) [1].
Product Specifications
CAS Number
[1174277-80-5]
Product Name Alternative
ENB-0040
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Inhibitory Antibodies
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/asfotase-alfa.html
Purity
98.53
Solubility
10 mM in DMSO
Smiles
[Asfotasealfa]
Molecular Weight
(161.135 kDa)
Precautions
H302, H315, H319, H335
References & Citations
[1]Yadav MC, et al. Dose response of bone-targeted enzyme replacement for murine hypophosphatasia. Bone. 2011 Aug;49 (2) :250-6.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Available Sizes
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