Isopedicin
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2-) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) -activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1].
Product Specifications
CAS Number
4431-42-9
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/isopedicin.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(OC)C(OC)=C1O
Molecular Formula
C18H18O6
Molecular Weight
330.33
References & Citations
[1]Hwang TL, et al. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46 (4) :520-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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