Isopedicin

Isopedicin potently and concentration-dependently inhibits superoxide anion (O2-) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) -activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1].

Product Specifications

CAS Number

[4431-42-9]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/isopedicin.html

Solubility

10 mM in DMSO

Smiles

COC1=C2C(O[C@H](C3=CC=CC=C3)CC2=O)=C(OC)C(OC)=C1O

Molecular Formula

C18H18O6

Molecular Weight

330.33

References & Citations

[1]Hwang TL, et al. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46 (4) :520-8.