Debutyldronedarone-d7

Debutyldronedarone-d7 is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans.Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].

Product Specifications

Product Name Alternative

SR35021-d7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CS(=O)(NC1=CC=C(OC(CCCC)=C2C(C3=CC=C(OCCCNCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C=C3)=O)C2=C1)=O

Molecular Formula

C27H29D7N2O5S

Molecular Weight

507.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Cen Xie, et al. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.J Chromatogr B Analyt Technol Biomed Life Sci|[2]Marina Santos, et al.Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride. J Pharm Biomed Anal. 2015 Oct 10;114:441-6.