YD54
YD54 is a PROTAC based SMARCA2 degrader with a DC50 of 3.5 nM (Red: SMARCA2 degrader (HY-44012B), black: linker, Blue: E3 ligase ligand) [1].
Product Specifications
CAS Number
[2951015-30-6]
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yd54.html
Purity
98.74
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3OCCN4CCN(C5=C(F)C=C(CN6CCN(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)CC6)C=C5)CC4
Molecular Formula
C40H42FN9O6
Molecular Weight
763.82
References & Citations
[1]Kotagiri S, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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