Guanidine thiocyanate

Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction[1].

Product Specifications

CAS Number

[593-84-0]

UNSPSC

12352200

Hazard Statement

H302+H312+H332, H314, H412

Target

Endogenous Metabolite

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/guanidine-thiocyanate.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

SC#N.NC(N)=N

Molecular Formula

C2H6N4S

Molecular Weight

118.16

Precautions

H302+H312+H332, H314, H412

References & Citations

[1]Michelle J Honeywood, et al. Use of guanidine thiocyanate-based nucleic acid extraction buffers to inactivate poliovirus in potentially infectious materials. J Virol Methods. 2021 Nov:297:114262.