Recombinant Human CCL7
Recombinant human CCL7
Product Specifications
Product Name Alternative
rHuCCL7, MCP-3
Gene Name
CCL7
UniProt
P80098
Cellular Locus
Secreted.
Reactivity
Human
Target Antigen
C-C motif chemokine 7
Target
CCL7
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration of recombinant CCR2- expressing cells.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/50188P.pdf
Specificity
CCL7
Target Background
CCL7, also known as Monocyte Chemotactic Protein-3 (MCP-3), is a secreted chemokine that attracts macrophages, monocytes, and eosinophils during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. In vivo, this protein is a substrate of matrix metalloproteinase 2 (MMP2), an enzyme that degrades components of the extracellular matrix. The gene that encodes CCL7 is part of a cluster of C-C chemokine family members on chromosome 17q. CCL7 binds to CCR1, CCR2, and CCR3 receptors and appears to be an antagonist for the CCR5 receptor.
CAS Number
9000-83-3
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