GPI-1046

GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core) . GPI-1046 improves human immunodeficiency virus (HIV) -associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity[1][2][3].

Product Specifications

CAS Number

[186452-09-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EAAT; HIV

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gpi-1046.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2

Molecular Formula

C20H28N2O4

Molecular Weight

360.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35.|[2]Höke A, et al. GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry. J Peripher Nerv Syst. 2009 Mar;14 (1) :27-35.|[3]Ganel R, et al. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol Dis. 2006 Mar;21 (3) :556-67.