Chenodeoxycholic Acid-d4
Chenodeoxycholic Acid-d4 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
Product Specifications
CAS Number
99102-69-9
Product Name Alternative
CDCA-d4
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Endogenous Metabolite; FXR
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Cancer
Purity
99.93
Solubility
DMF : ≥ 30mg/mL|DMSO : ≥ 20mg/mL|Ethanol : ≥ 20mg/mL
Smiles
O[C@@H]1C([2H])(C[C@]2([C@@]([H])(C1([2H])[2H])C[C@H]([C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)[H])[H])O)C)[2H]
Molecular Formula
C24H36D4O4
Molecular Weight
396.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11 (14) :2699-710|[3]Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277 (29) :26286-92|[4]Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208 (1) :405-11.|[5]Ao M, et al. Chenodeoxycholic acid stimulates Cl (-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305 (4) :C447-56|[6]Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2472806 100 µL
TGF beta Receptor III Rabbit Polyclonal Antibody (BF405)
Sign In for Pricing
View Details 
248142-AP 100 µL
LGALS1 (Lectin, Galactoside-Binding, Soluble, 1, DKFZp686E23103, GAL1, GBP) (AP) discontinued
Sign In for Pricing
View Details 
GTR15349514 1 Vial
Lentiviral human OR6B1 shRNA (UAS) - Lentiviral human OR6B1 shRNA (UAS, RFP) (25)
Sign In for Pricing
View Details