PDE10A-IN-2 (hydrochloride)
Product Specifications
UNSPSC Description
PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pde10a-in-2-hydrochloride.html
Purity
98.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCN(CCCOC2=CC(N3C(/C=C/C4=C5N=CC=CC5=CC=C4)=NC6=CC(C)=CC=C36)=CC=C2)CC1.[H]Cl.[H]Cl.[H]Cl
Molecular Weight
627.05
References & Citations
[1]Yuncong Yang, et al. Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension. Acta Pharm Sin B. 2020 Dec;10(12):2339-2347.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131973/PDE10A-IN-2-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131973/PDE10A-IN-2-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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