UDP-GlcNAz (disodium)

UDP-GlcNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is the analogue of UDP-GlcNAc (HY-112174) . UDP-GlcNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GlcNAc from the nucleotide sugar to a saccharide or peptide acceptor[1]. UDP-GlcNAc (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1611490-64-2]

UNSPSC

12352200

Target

Biochemical Assay Reagents; Glycosidase; OGT

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/udp-glcnaz-disodium.html

Purity

99.74

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(CN=[N+]=[N-])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O

Molecular Formula

C17H24N6Na2O17P2

Molecular Weight

692.33

References & Citations

[1]Vocadlo DJ, et, al. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A. 2003 Aug 5;100 (16) :9116-21.|[2]Kim EJ, et al. Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug Chem. 2014 Jun 18;25 (6) :1025-30.