3’-O- (2-Methoxyethyl) guanosine

3’-O- (2-Methoxyethyl) guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

Product Specifications

CAS Number

[256224-03-0]

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3-o-2-methoxyethyl-guanosine.html

Concentration

10mM

Purity

98.90

Solubility

DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]1[C@@H](OCCOC)[C@@H](O)[C@H](N(C=N2)C3=C2C(NC(N)=N3)=O)O1

Molecular Formula

C13H19N5O6

Molecular Weight

341.32

References & Citations

[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.