Dimethylcurcumin

Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.

Product Specifications

CAS Number

[52328-98-0]

Product Name Alternative

ASC-J9; GO-Y025

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor

Type

Natural Products

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/asc-j9.html

Purity

98.06

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(/C=C(O)/C=C/C1=CC=C(OC)C(OC)=C1)/C=C/C2=CC=C(OC)C(OC)=C2

Molecular Formula

C23H24O6

Molecular Weight

396.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Yamashita S, et al.  ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia. 2012 Jan;14 (1) :74-83.|[2]Yang Z, et al.  ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007 Mar;13 (3) :348-53.|[3]Lee SO, et al.  New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs non-stem/progenitor cells. J Mol Cell Biol. 2012 Jul 24.|[4]Ma W, et al. Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. Biochem Biophys Res Commun. 2017 Apr 15;485 (4) :746-752. doi: 10.1016/j.bbrc.2017.02.123. Epub 2017 Feb 27.