GNE 5729
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Product Specifications
CAS Number
[2026635-66-3]
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE_5729.html
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C([C@H]2[C@H](C#N)C2)N3C(C=C1)=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC3=O
Molecular Formula
C17H10Cl2F3N5O
Molecular Weight
428.20
References & Citations
[1]Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8 (1) :84-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6484590-01 0.2 mL
KvLQT1 (Potassium Voltage-gated Channel Subfamily KQT Member 1, KCNQ1, ATFB1, ATFB3, FLJ26167, IKs Producing Slow Voltage-gated Potassium Channel Subunit alpha KvLQT1, JLNS1, KCNA8, KCNA9, KQT-like 1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, Voltage-gated Pota
Ask
View Details MBS6484590-02 5x 0.2 mL
KvLQT1 (Potassium Voltage-gated Channel Subfamily KQT Member 1, KCNQ1, ATFB1, ATFB3, FLJ26167, IKs Producing Slow Voltage-gated Potassium Channel Subunit alpha KvLQT1, JLNS1, KCNA8, KCNA9, KQT-like 1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, Voltage-gated Pota
Ask
View Details