Dutogliptin
Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
Product Specifications
CAS Number
852329-66-9
Product Name Alternative
PHX-1149 (free base)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Dutogliptin.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 300 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(CN[C@@H]1CCNC1)N(CCC2)[C@@H]2B(O)O
Molecular Formula
C10H20BN3O3
Molecular Weight
241.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3 (4) :297-304.|[2]Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12 (4) :348-55.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
DPP-4
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