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Dutogliptin

Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

Product Specifications

CAS Number

852329-66-9

Product Name Alternative

PHX-1149 (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Dutogliptin.html

Concentration

10mM

Purity

99.32

Solubility

DMSO : 300 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(CN[C@@H]1CCNC1)N(CCC2)[C@@H]2B(O)O

Molecular Formula

C10H20BN3O3

Molecular Weight

241.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3 (4) :297-304.|[2]Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12 (4) :348-55.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

DPP-4

Available Sizes

Frequently Asked Questions

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