Rocbrutinib

Rocbrutinib is a Bruton's tyrosine kinase inhibitor with antineoplastic effect[1].

Product Specifications

CAS Number

[2485861-07-0]

Product Name Alternative

LP-168

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rocbrutinib.html

Purity

99.76

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=CC(CC(C)(C3)C)=C3N2CCN1C4=C(C(C(N=C5NC6=CC(NC(C=C)=O)=C(N7[C@H](CN(C8CCOCC8)CC7)C)C=C6)=CN(C)C5=O)=CC=N4)CO

Molecular Formula

C42H51N9O5

Molecular Weight

761.91

References & Citations

[1]Chen Yi, et al. Preparation of pyrrolopyrazines and related heterocycles as inhibitors of BTK and mutants thereof for the treatment of neoplastic, autoimmune and inflammatory disorders. World Intellectual Property Organization, WO2020176403 A1 2020-09-03.