Desloratadine

Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria[1][2][3][4][5][6].

Product Specifications

CAS Number

[100643-71-8]

Product Name Alternative

Sch34117

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor; Leukotriene Receptor; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Desloratadine.html

Purity

99.98

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1

Molecular Formula

C19H19ClN2

Molecular Weight

310.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107 (4) : p. 751-62.|[2]Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31 (9) : p. 1369-77.|[3]Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H (1) receptor. Eur J Pharmacol, 2002. 449 (3) : p. 229-37.|[4]McClellan K, et al. Desloratadine. Drugs. 2001;61 (6) :789-797.|[5]Agrawal, et al. "Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug." Expert opinion on investigational drugs 10.3 (2001) : 547-560.|[6]Kowalski, et al. "Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine." Allergy 60.1 (2005) : 80-85.