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L-Azidohomoalanine

L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[120042-14-0]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-azidohomoalanine.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H](N)CCN=[N+]=[N-]

Molecular Formula

C4H8N4O2

Molecular Weight

144.13

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl-Chain Linkers

Citation 01

Microbiol Spectr. 2021 Dec 22;9 (3) :e0109421.|Cell Biosci. 2022 Dec 21;12 (1) :206.|Nat Commun. 2024 Jun 28;15 (1) :5481.|Redox Biol. 2022 Jun:52:102284.
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