iNOS/TopoI-IN-1
Product Specifications
UNSPSC Description
iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM)[1].
Target Antigen
Apoptosis; NF-κB; NO Synthase; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/inos-topoi-in-1.html
Smiles
CC1=CC=C(C)C2=C1N(CCCCCCCCS[Au]C3N(CC(O)C4=CC=CC=C4)C(Cl)=C(Cl)N3C)C5=CC=C(Br)C=C25
Molecular Weight
886.54
References & Citations
[1]D'Amato, et al. "Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au (I) complexes and carbazole moieties." European Journal of Medicinal Chemistry (2024): 116757.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162805/iNOS-TopoI-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162805/
Clinical Information
No Development Reported
Curated Selection
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