FTO-IN-8
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity[1].
Product Specifications
CAS Number
[2640366-38-5]
UNSPSC
12352005
Target
Fat Mass and Obesity-associated Protein (FTO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fto-in-8.html
Purity
95.04
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC=CC=C1C2=CC=C(CNCC3(N4CCCC4)COC3)O2
Molecular Formula
C19H23ClN2O2
Molecular Weight
346.85
References & Citations
[1]Sarah Huff, et al. Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents. J Med Chem. 2022 Aug 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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