NUCC-555
NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice[1][2].
Product Specifications
CAS Number
1060469-90-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nucc-555.html
Smiles
O=C(NCC1=CC=CC=C1)C2=CC(NC(COC)=O)=CC3=C2N(C(C4=CC=CN=C4)=N3)CC
Molecular Formula
C25H25N5O3
Molecular Weight
443.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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