Caryophyllene oxide

Caryophyllene oxide ((-) -Caryophyllene oxide) is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties[1][2][3].

Product Specifications

CAS Number

[1139-30-6]

Product Name Alternative

(-) -Caryophyllene oxide

UNSPSC

12352005

Hazard Statement

H315, H319, H411

Target

Apoptosis; Bacterial; Fungal; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/caryophyllene-oxide.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

C=C1CC[C@@]2([H])O[C@]2(C)CC[C@@]3([H])C(C)(C)C[C@]13[H]

Molecular Formula

C15H24O

Molecular Weight

220.35

Precautions

H315, H319, H411

References & Citations

[1]Chavan MJ, et al. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine. 2010 Feb;17 (2) :149-51.|[2]Delgado C, et al. Caryophyllene Oxide, the Active Compound Isolated from Leaves of Hymenaea courbaril L. (Fabaceae) with Antiproliferative and Apoptotic Effects on PC-3 Androgen-Independent Prostate Cancer Cell Line. Molecules. 2021 Oct 12;26 (20) :6142. |[3]Coté H, et al. Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents. Medicines (Basel) . 2017 May 25;4 (2) :34.