CL 5343 (Standard)

CL 5343 (Standard) is the analytical standard of CL 5343. This product is intended for research and analytical applications. CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B) . CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells[1][2].

Product Specifications

CAS Number

[14949-00-9]

Product Name Alternative

5-Amino-1,3,4-thiadiazole-2-sulfonamide (Standard)

UNSPSC

12352005

Target

Carbonic Anhydrase; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cl-5343-standard.html

Smiles

O=S(C1=NN=C(N)S1)(N)=O

Molecular Formula

C2H4N4O2S2

Molecular Weight

180.21

References & Citations

[1]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14 (4) :689-693.|[2]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11 (8) : 2243-2264.