CL 5343 (Standard)
CL 5343 (Standard) is the analytical standard of CL 5343. This product is intended for research and analytical applications. CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B) . CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells[1][2].
Product Specifications
CAS Number
14949-00-9
Product Name Alternative
5-Amino-1,3,4-thiadiazole-2-sulfonamide (Standard)
UNSPSC
12352005
Target
Carbonic Anhydrase; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cl-5343-standard.html
Smiles
O=S(C1=NN=C(N)S1)(N)=O
Molecular Formula
C2H4N4O2S2
Molecular Weight
180.21
References & Citations
[1]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14 (4) :689-693.|[2]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11 (8) : 2243-2264.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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