TAS-103 (dihydrochloride)

TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.

Product Specifications

CAS Number

[174634-09-4]

Product Name Alternative

BMS-247615 dihydrochloride

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TAS-103-dihydrochloride.html

Purity

98.45

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C3=CC=C(O)C=C3N=C1NCCN(C)C)C4=C2C=CC=C4.Cl.Cl

Molecular Formula

C20H21Cl2N3O2

Molecular Weight

406.31

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Padget K, et al. An investigation into the formation of N- [2- (dimethylamino) ethyl]acridine-4-carboxamide (DACA) and 6-[2- (dimethylamino) ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000 Sep 15;60 (6) :817-21.|[2]Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12- (dimethylamino) ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25 (10) :1385-7.|[3]Yoshida M, et al. A new mechanism of 6- ((2- (dimethylamino) ethyl) amino) -3-hydroxy-7H-indeno (2,1-c) quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008 Mar;73 (3) :987-94. Epub 2007 Dec 18.