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FHT-2344

FHT-2344, a chemical probe, is a SMARCA4/SMARCA2 ATPase inhibitor with IC50 values of 0.026 μM and 0.013 μM, respectively. FHT-2344 has anticancer activity[1].

Product Specifications

CAS Number

[2468058-90-2]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fht-2344.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(C=C1)S(C)(=O)=O)N[C@@H](COC)C(NC2=NC(C3=CC(C4=NN(C=C4)C)=CC=C3)=CS2)=O

Molecular Formula

C23H24N6O5S2

Molecular Weight

528.60

References & Citations

[1]Centore R C, et al. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers[J]. bioRxiv, 2023: 2023.09. 11.557162.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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