(R) -DRF053 (dihydrochloride)
(R) -DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R) -DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].
Product Specifications
CAS Number
[1241675-76-2]
UNSPSC
12352005
Target
Casein Kinase; CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-drf053-dihydrochloride.html
Purity
99.30
Solubility
DMSO : 49.04 mg/mL (ultrasonic; warming)
Smiles
CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl
Molecular Formula
C23H29Cl2N7O
Molecular Weight
490.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; CK1
Available Sizes
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