(R) -DRF053 (dihydrochloride)

(R) -DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R) -DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

Product Specifications

CAS Number

[1241675-76-2]

UNSPSC

12352005

Target

Casein Kinase; CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-drf053-dihydrochloride.html

Purity

99.30

Solubility

DMSO : 49.04 mg/mL (ultrasonic; warming)

Smiles

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl

Molecular Formula

C23H29Cl2N7O

Molecular Weight

490.43

References & Citations

[1]Nassima Oumata, et al. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem. 2008 Sep 11;51 (17) :5229-42.