Cariprazine-d8
Product Specifications
UNSPSC Description
Cariprazine-d8 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
Target Antigen
5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein;Neuronal Signaling;Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=CC=C1Cl)N2C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C2([2H])[2H])CC[C@@H]3CC[C@H](CC3)NC(N(C)C)=O
Molecular Weight
435.46
References & Citations
[1]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
CAS Number
1308278-50-3
Available Sizes
Curated Selection
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