OPB-171775
Product Specifications
UNSPSC Description
OPB-171775 is a molecular glue, which forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway, and exhibits antitumor efficacy[1].
Target Antigen
Molecular Glues; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/opb-171775.html
Solubility
DMSO : ≥ 125 mg/mL
Smiles
FC1=C(C([C@H](C)C2)=NNC2=O)C=CC(OCC(O)(C)C)=C1F
Molecular Weight
312.31
References & Citations
[1]Takaki EO, et al., A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors. Clin Cancer Res. 2024 Jun 12.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162730/OPB-171775-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162730/OPB-171775-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2131210-15-4
Available Sizes
Curated Selection
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