OPB-171775

OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) . OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor[1].

Product Specifications

CAS Number

[2131210-15-4]

UNSPSC

12352101

Target

Molecular Glues; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/opb-171775.html

Purity

99.80

Solubility

DMSO : ≥ 125 mg/mL

Smiles

FC1=C(C([C@H](C)C2)=NNC2=O)C=CC(OCC(O)(C)C)=C1F

Molecular Formula

C15H18F2N2O3

Molecular Weight

312.31

References & Citations

[1]Takaki EO, et al., A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors. Clin Cancer Res. 2024 Jun 12.