Naxagolide
Naxagolide ((+) -PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD) [1][2].
Product Specifications
CAS Number
[88058-88-2]
Product Name Alternative
(+) -PHNO; Dopazinol
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/naxagolide.html
Purity
98.85
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC
Molecular Formula
C15H21NO2
Molecular Weight
247.33
References & Citations
[1]G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+) -4-propyl-9-hydroxynaphthoxazine [ (+) -PHNO]. J Pharmacol Exp Ther. 1984 Sep;230 (3) :569-76.|[2]E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265 (3) :1387-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
D2 Receptor
Available Sizes
Curated Selection
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