EC-17 (disodium salt)

EC-17 disodium salt is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively[1][2].

Product Specifications

CAS Number

[910661-33-5]

UNSPSC

12171500

Target

Fluorescent Dye; Folate Receptor (FR)

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EC-17_disodium_salt.html

Purity

96.30

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

S=C(NCCNC(CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O)=O)NC4=CC5=C(C6(C7=C(OC8=C6C=CC(O)=C8)C=C(O[Na])C=C7)OC5=O)C=C4

Molecular Formula

C42H34N10Na2O10S

Molecular Weight

916.82

References & Citations

[1]Tummers QR, et al. Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget. 2016 May 31;7 (22) :32144-55.|[2]Patil RA, et al. Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry. Mol Imaging Biol. 2020 Oct;22 (5) :1280-1289.